RASGRP1 antibody

Catalog No. ABIN6566956

The Rabbit Polyclonal anti-RASGRP1 antibody has been validated for WB. It is suitable to detect RASGRP1 in samples from Human.

Quick Overview for RASGRP1 antibody (ABIN6566956)

Target: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RASGRP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RASGRP1 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human RASGRP1

Isotype: IgG

Application Details

Application Notes: WB 1:1000 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RASGRP1

Target: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Alternative Name: RASGRP1

Background:

Synonyms: Calcium and DAG-regulated guanine nucleotide exchange factor II,CALDAG-GEFI,CalDAG-GEFII,GRP1,Guanine nucleotide exchange factor, calcium and DAG regulated, Rap1A,hRasGRP1,Ras activator RasGRP,RAS guanyl nucleotide releasing protein 1,RAS guanyl releasing protein 1 (calcium and DAG-regulated),RAS guanyl releasing protein 1,RAS guanyl-releasing protein 1,Ras guanyl-releasing protein,RASGRP,rasgrp1,V

Background: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).

Molecular Weight:

Observed_MW: 90kDa

Calculated_MW: 55kDa/62kDa/68kDa/86kDa/90kDa

Gene ID: 10125

UniProt: O95267

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway